6th EFMC Young Medicinal Chemist Symposium
Athens, Greece September 5-6, 2019
Registration
Welcome and Opening
Session Chair:
Dr Emmanouil FOUSTERIS
UNIVERSITY OF PATRAS, Patras, Greece
KL01 - The Emergence of Antibody-Drug Conjugates (ADCs) as Targeted Cancer Therapies: From Ehrlich's "Magic Bullet" Concept to Calicheamicin γ1I and Mylotarg
Prof. K.C. NICOLAOU
RICE UNIVERSITY, Houston, United States
OC01 - Functionalization of Tumour-Targeting Antibodies Via Enzymatic Oxidation of Tyrosine to 1,2-Quinones
Winner of the Young Medicinal Chemist Meeting in The Netherlands
Mr Jorick BRUINS
WAGENINGEN UNIVERSITY, WAGENINGEN, The Netherlands
OC02 - Synthetic Small Molecules Interfering with Oncogenic Micrornas for the Induction of Glioblastoma Stem Cells Differentiation
Winner of the Young Medicinal Chemist Meeting in France
Ms Chloé MAUCORT
INSTITUTE OF CHEMISTRY OF NICE, Nice, France
OC03 -New Ruthenium-Cyclopentadienyl Complexes Bearing Biotinylated (Macro)Ligands: Targeting Strategies to Fight Metastatic Breast Cancer
Winner of the Young Medicinal Chemist Meeting in Portugal
Dr Leonor CORTE-REAL
CENTRO DE QUÍMICA ESTRUTURAL, Lisboa, Portugal
Flash Poster Presentations (01-10)
FP01 - A New Life for Diazaborines: the Next Generation of Serine Protease Inhibitors
Mr Joao ANTONIO
UNIVERSITY OF LISBON, Lisbon, Portugal
FP02 - From Peptides to Peptidomimetics: Structure-Activity Relationship of a Factor H-Binding Peptide to Modulate Undesired Host Complement Activity
Mr Clément BECHTLER
UNIVERSITY OF BASEL, Basel, Switzerland
FP03 - Matrix Metalloproteinase-12 Inhibitors: Synthesis, Structure-Activity Relationships and Intestinal Absorption of Novel Sugar-Based Biphenylsulfonamide Carboxylates
Dr Doretta CUFFARO
UNIVERSITY OF PISA, Pisa, Italy
FP04 - Photophysical Properties and Antiparasitic Activity of Bodipy-Tethered Dinuclear Trithiolato-Bridged Ruthenium(II)-Arene Complexes
Mrs Oksana DESIATKINA
UNIVERSITY OF BERN, Bern, Switzerland
FP05 - N-ALKYL L-Iminosugars as Novel Anti-Inflammatory and Anti-Biofilm Tools for Cystic Fibrosis Lung Infections
Ms Anna ESPOSITO
UNIVERSITY OF NAPOLI FEDERICO II, Napoli, Italy
FP06 - Design, Synthesis and Biological Evaluation of Novel Substituted Purine Isosters as EGFR Kinase Inhibitors, with Promising Pharmacokinetic Profile and In Vivo Efficacy
Dr Efthymios-Spyridon GAVRIIL
NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS, Athens, Greece
FP07 - Metal-Chelating Acetohydroxamic Acids Against Hepatitis C Virus and Flaviviruses
Ms Erofili GIANNAKOPOULOU
NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS, Athens, Greece
FP08 - Discovery of Small-Molecule Modulators of 14-3-3 PPIs Via Dynamic Combinatorial Chemistry
Mr Alwin HARTMAN
UNIVERSITY OF GRONINGEN, Groningen, The Netherlands
FP09 - Purine Nucleoside Analogs as Highly Potent Leads for the Treatment of Human African Trypanosomiasis
Dr Fabian HULPIA
UGENT, Ghent, Belgium
FP10 - Development of Allosteric Inhibitors of ColH Using DCC Strategy
Dr Jelena KONSTANTINOVIC
HELMHOLTZ INSTITUTE FOR PHARMACEUTICAL RESEARCH SAARLAND (HIPS), Saarbrücken, Germany
Coffee Break
Session Chair:
Dr Kristina GONCHARENKO
SPIROCHEM AG, Basel, Switzerland
OC04 - Novel Acridine Derivatives as TDP 1 and/or 2 Inhibitors
Winner of the Young Medicinal Chemist Meeting in Greece
Mrs Maria KARELOU
NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS, Athens, Greece
OC05 - Discovery of a Novel Chemotype of Non-Acidic, Neutral and Macrocyclic Keap1 Inhibitors
Winner of the Young Medicinal Chemist Meeting in Sweden
Mr Fabio BEGNINI
UPPSALA UNIVERSITY, Uppsala, Sweden
OC06 - Directed Evolution of Short Peptides for Selective Detoxification of Lead
Winner of the Young Medicinal Chemist Meeting in Switzerland
Dr Michal SHOSHAN
UNIVERSITY OF ZURICH, Zürich, Switzerland
Flash Poster Presentations (11-20)
FP11 - Identification, Synthesis and Optimization of Inhibitors of the Protein Tyrosine Phosphatase SHP2
Dr Yelena MOSTINSKI
LEIBNIZ-FORSCHUNGSINSTITUT FÜR MOLEKULARE PHARMAKOLOGIE, Berlin, Germany
FP12 - Multitarget Triazoles: an Innovative Approach for the Treatment of Alzheimer’s Disease
Ms Vanesa NOZAL GARCIA
CIB - CSIC, Madrid, Spain
FP13 - TDP-43 Modulation by CDC7 Inhibitors as a Therapeutic Strategy for Amyotrophic Lateral Sclerosis
Ms Elisa ROJAS
CIB - CSIC, Madrid, Spain
FP14 - Use of the 4-Hydroxy-Triazole Moiety as a Bioisosteric Tool in the Development of Selective Ligands for Subtypes Ampa Receptor
Dr Stefano SAINAS
UNIVERSITY OF TORINO, Torino, Italy
FP15 - In Vitro and In Ovo Evaluation of Ros-Activatable Anticancer Boronate Prodrugs of Doxorubicin
Dr Charles SKARBEK
UNIVERSITY PARIS SUD, Orsay, France
FP16 - Design and Synthesis of Tead's Ligands for the Treatment of Cancers
Mrs Manon STURBAUT
UNIVERSITY OF LILLE, Lille, France
FP17 - Drug-Fragment Based Explorations for Novel Enterovirus Inhibitors
Ms Clara VAN HOEY
UNIVERSITY OF VIENNA, Vienna, Austria
FP18 - Gemcitabine-GnRH Bioconjugates Bearing Oxime Bond Linkages: Synthesis, In Vitro Stability, Drug Release and Cytotoxic Effect
Mr Eirinaios VRETTOS
UNIVERSITY OF IOANNINA, Ioannina, Greece
FP19 - Development of GSTO1-1 Inhibitors for the Treatment of Inflammatory Conditions
Ms Yiyue XIE
MONASH UNIVERSITY, Melbourne, Australia
FP20 - Identification of a Novel Quinoline-Based DNA Demethylating Compound Highly Potent in Cancer Cells
Dr Clemens ZWERGEL
UNIVERSITY OF ROME LA SAPIENZA, Rome, Italy
EFMC-YMCS Poster Presentation Session 1 (Odd), Bites & Drinks
EFMC-YMCS Poster Presentation Session 2 (Even), Bites & Drinks
End of the Scientifc Programme
How to Boost Your Oral Presentation Skill, and Create a Good Slideshow
Dr Kristina GONCHARENKO
SPIROCHEM AG, Basel, Switzerland
Getting the Job You Deserve!
Dr. David ALKER
DAVID ALKER ASSOCIATES, Birchington, United Kingdom
EFMC-YSN Networking Event
End of the Day
Session Chair:
Dr Cassandra LEE FLEMING
UNIVERSITY OF GOTHENBURG, Gothenburg, Sweden
KL02 - Medicinal Chemistry Between Serendipity and (Artificial) Intelligence
Dr Cornelia ZUMBRUNN
IDORSIA PHARMACEUTICALS, Allschwil, Switzerland
OC07 - Antiplasmodial Activity of SAHAquines, Novel SAHA - Primaquine Hybrids
Winner of the Young Medicinal Chemist Meeting in Croatia
Ms Maja BEUS
UNIVERSITY OF ZAGREB, Zagreb, Croatia
OC08 - Hybrdization Approach Towards Novel Antituberculars: Design, Synthesis, And Antimicrobial Evaluation Hybrid Compounds Combining Pyrazinamide and p Aminosalicylic Acid
Winner of the Young Medicinal Chemist Meeting in Czech Republic
Ms Ghada BOUZ
CHARLES UNIVERSITY, Hradec Kralove, Czech Republic
OC09 - Synthesis, Computational and Biological Evaluation of Novel Benzimidazole Compounds for the Treatment of Cryptococcus Neoformans
Winner of the Young Medicinal Chemist Meeting in the United Kingdom
Ms Gina WASHBOURN
UNIVERSITY OF LIVERPOOL, Liverpool, United Kingdom
OC10 - Nʼ-Benzylated Derivatives of N-(7-Chloroquinolin-4-Yl)Octane-1,8-Diamine as Quorum Sensing Inhibitors in Pseudomonas Aeruginosa
Winner of the Young Medicinal Chemist Meeting in Serbia
Ms Marta SPASIC
UNIVERSITY OF BELGRADE, Nis, Serbia
Coffee Break
Session Chair:
Dr Eleni PONTIKI
ARISTOTELE UNIVERSITY OF THESSALONIKI, Thessaloniki, Greece
OC11 - Geometric Isomers of N-Propargyl-4-Syrylpiperidine Discriminate Between Monoamine Oxidase Isoforms A and B
Winner of the Young Medicinal Chemist Meeting in Slovenia
Dr Damijan KNEZ
UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia
OC12 A Fusing Strategy Application: Towards Potent ChE Inhibitors With MTDL Profile
Winner of the Young Medicinal Chemist Meeting in Turkey
Ms Gülsah BAYRAKTAR
EGE UNIVERSITY FACULTY OF PHARMACY, Izmir, Turkey
OC13 - Development of Unique Molecular Probes: Low-Basicity Agonists for the Study of 5-HT7 Receptor Function
Winner of the Young Medicinal Chemist Meeting in Poland
Dr Adam HOGENDORF
MAJ INSTITUTE OF PHARMACOLOGY, POLISH ACADEMY OF SCIENCES, Krakow, Poland
OC14 - The Establishment of Tocopherol Reference Intervals for Hungarian Adult Population Using Validated HPLC Method
Winner of the Young Medicinal Chemist Meeting in Hungary
Dr Gábor VERES
HUNGARIAN ACADEMY OF SCIENCES, Budapest, Hungary
Lunch
Why Was My Paper Rejected? Tips from an Editor on How to Get Published
Dr David PERALTA
WILEY-VCH VERLAG GMBH & CO. KGAA, Weinheim, Germany
Session Chair:
Prof. Grigorios ZOIDIS
UNIVERSITY OF ATHENS, Athens, Greece
OC15 - Expanding the Chemical Space of DNA-Encoded Small Molecule Libraries
Winner of the Young Medicinal Chemist Meeting in Germany
Dr Andreas BRUNSCHWEIGER
TU DORTMUND, Dortmund, Germany
OC16 - Finding the Right Candidate for the Right Position: a Fast NMR-Assisted Combinatorial Method for Optimizing Nucleic Acids Binders
Winner of the Young Medicinal Chemist Meeting in Spain
Dr Andrés GONZALEZ SANTANA
IQOG - CSIC, Madrid, Spain
OC17 - From ZINC to ZINClick: Our Way to Explore the Chemical Space
Winner of the Young Medicinal Chemist Meeting in Italy
Dr Alberto MASSAROTTI
UNIVERSITY OF EASTERN PIEDMONT, Novara, Italy
OC18 - Extended Glucuronides: Achieving Site-Selectivity Through Extracellular Drug Release
Winner of the Young Medicinal Chemist Meeting in Denmark
Mr Raoul WALTHER
AARHUS UNIVERSITY, Aarhus, Denmark
OC19 - Cyclopropenium-Based Polymers
Winner of the Young Medicinal Chemist Meeting in Israel
Mr Noam STEINMAN
HEBREW UNIVERSITY OF JERUSALEM, Jerusalem, Israel
Voting Break
KL03 - Chemical Tools to Target and Image Tumours
Prof. Stuart CONWAY
UNIVERSITY OF OXFORD, Oxford, United Kingdom
Closing and Award Ceremony
End of the Symposium